Upon conversion to the active GTP bound form

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wholesale jerseys In the absence of ligand, the GPCR associates with an inactive GDP bound complex. Upon ligand engagement, the GPCR assumes an active configuration and functions as a guanine nucleotide exchange factor (GEF), catalyzing the exchange of GDP for GTP on the G subunit. Upon conversion to the active GTP bound form, the G subunit will dissociate from the G subunit and each component is free to elicit a distinct array of effector functions. wholesale jerseys

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